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Our previous studies using vertebrate and invertebrate models showed that the canonical role of syndecans in controlling cell behavior is to repress transient receptor potential canonical (TRPC) channel function and thereby limit cellular Ca 2+ influx 3

Rodriguez PJ, Zhang V, Gratzl S, Do D, Goodwin Cartwright B, Baker C, Gluckman TJ, Stucky N, Emanuel EJ

Accordingly, administration of Ang-(1-7) and its synthetic analogue AVE 00991 have been reported to reduce leukocyte adhesion to the microvascular endothelium in a model of arthritis (Simes e Silva et al., 2013)

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